Reviewed by PeptideGuide Research Team|Last updated February 15, 2026
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Matrixyl (Palmitoyl Pentapeptide-4) vs Argireline (Acetyl Hexapeptide-3)
Complete side-by-side comparison of Matrixyl (Palmitoyl Pentapeptide-4) and Argireline (Acetyl Hexapeptide-3).
Side-by-Side Comparison
Property
Matrixyl (Palmitoyl Pentapeptide-4)
Argireline (Acetyl Hexapeptide-3)
Name
Matrixyl (Palmitoyl Pentapeptide-4)
Argireline (Acetyl Hexapeptide-3)
Peptide Class
Cosmetic Peptide
Cosmetic Peptide
Category
Skin and Cosmetic
Skin and Cosmetic
Dosage Range
N/A
N/A
Half-Life
N/A
N/A
FDA Status
Not FDA approved for medical use
Not FDA approved for medical use
Safety Rating
Generally Well-Tolerated
Generally Well-Tolerated
Cost Estimate
$30-60 per month
$20-50/month
Matrixyl (Palmitoyl Pentapeptide-4)
Matrixyl, also known as Palmitoyl Pentapeptide-4, is a cosmetic peptide primarily used in anti-aging skincare products. It is renowned for its ability...
View full profile →Argireline (Acetyl Hexapeptide-3)
Argireline, also known as Acetyl Hexapeptide-3, is a cosmetic peptide widely used in anti-aging skincare products. It functions by inhibiting neurotra...
View full profile →