Reviewed by PeptideGuide Research Team|Last updated February 15, 2026
Medical Disclaimer
This content is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before using any peptide.Read full disclaimer
Back to Comparisons
Setmelanotide vs Semaglutide
Complete side-by-side comparison of Setmelanotide and Semaglutide.
Side-by-Side Comparison
Property
Setmelanotide
Semaglutide
Name
Setmelanotide
Semaglutide
Peptide Class
Melanocortin receptor agonist
Glucagon-like peptide-1 (GLP-1) receptor agonist
Category
Melanocortin
Weight Loss and Metabolic
Dosage Range
1-3 mg per day
0.25 mg to 2.4 mg weekly
Half-Life
11 hours
Approximately 7 days
FDA Status
Approved
Approved for Type 2 Diabetes and Weight Management
Safety Rating
Prescription Required
Prescription Required
Cost Estimate
$500-800 per cycle
$800-1200/month
Setmelanotide
Setmelanotide is a potent melanocortin-4 receptor agonist specifically designed for the treatment of rare genetic disorders that lead to obesity. By t...
View full profile →Semaglutide
Semaglutide is a GLP-1 receptor agonist primarily used for managing type 2 diabetes and aiding in weight loss. It works by mimicking the GLP-1 hormone...
View full profile →