Reviewed by PeptideGuide Research Team|Last updated February 15, 2026
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Tirzepatide vs Semaglutide
Complete side-by-side comparison of Tirzepatide and Semaglutide.
Side-by-Side Comparison
Property
Tirzepatide
Semaglutide
Name
Tirzepatide
Semaglutide
Peptide Class
Dual GIP and GLP-1 receptor agonist
Glucagon-like peptide-1 (GLP-1) receptor agonist
Category
Weight Loss and Metabolic
Weight Loss and Metabolic
Dosage Range
5 mg to 15 mg once weekly
0.25 mg to 2.4 mg weekly
Half-Life
5 days
Approximately 7 days
FDA Status
Approved
Approved for Type 2 Diabetes and Weight Management
Safety Rating
Prescription Required
Prescription Required
Cost Estimate
$500-800 per cycle
$800-1200/month
Tirzepatide
Tirzepatide is a novel dual agonist peptide that targets both the GIP and GLP-1 receptors, offering a unique approach to managing obesity and type 2 d...
View full profile →Semaglutide
Semaglutide is a GLP-1 receptor agonist primarily used for managing type 2 diabetes and aiding in weight loss. It works by mimicking the GLP-1 hormone...
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